Bryan Willey Alzheimer’s disease Alzheimer’s is a progressive, degenerative disease of the brain and individuals with the disease suffer from many symptoms such as memory loss, agitation, impaired judgment, and difficulty communicating with others. The different lobes affected include the parietal lobe which deals with language, temporal lobe which deals with memory and frontal lobe which deals with behavior and judgment. The specific type of memory loss that an Alzheimer’s patient deals with is declarative memory. Declarative memory is remembrance of facts such as people’s names, what their faces look like and important dates from our past (Marieb and Hoehn 2013). The formation of these memories can only happen when the temporal lobe or more specifically the hippocampus are able to receive acetylcholine inputs. Patients with Alzheimer’s loose this input which prevents making new memories and remembering old ones (Marieb and Hoehn 2013). There are three different abnormalities that can make up Alzheimer’s disease. The first abnormality is beta-amyloid peptide cut from APP, a membrane precursor protein (Marieb and Hoehn 2013). Too much beta-amyloid is toxic and causes plaque buildup between neurons that reduces levels of acetylcholine which makes is difficult to retrieve old memories and make new ones (Marieb and Hoehn 2013). Another abnormality of Alzheimer’s disease is the presence of neurofibrillary tangles inside the neuron. These tangles consist of tau, a protein that leaves its stabilizing role and binds to another tau molecule forming a neurofibrillary tangle. (Marieb and Hoehn 2013). Neurofibrillary tangles then kill the neuron. The final abnormality of Alzheimer’s disease is brain shrinkage. The brain shrink... ... middle of paper ... ... conclude that Alzheimer’s disease is becoming more common and the facts back that up. Just in a span of fourteen years the annual deaths related to Alzheimer’s has become twenty-five times greater. Both by external sources demonstrate that Alzheimer’s has been a problem for a while and will continue to increase if we do not find more efficient treatment methods in the near future. Works Cited Marieb, E.N., Hoehn, K. 2013. Human Anatomy and Physiology. 9th edition. Pearson Education Inc. ISPN-13: 978-0-321-74326-8. The Editorial Board. High Mortality from Alzheimer’s in 2014. The Opinion Pages. Available from: http://nytimes.com/2014/03/23/opinion/high-mortality-from-alzheimers-disease.html Hoyert, DL., Rosenberg, HM. Mortality from Alzheimer's disease: an update in 1999. Available from: http://www.ncbi.nlm.nih.gov/pubmed/10459279
The sixth leading cause of death in the United States, Alzheimer’s disease afflicts approximately 5.2 million persons age 65 and over (Alzheimer's Association, 2012). Rapid growth of the older population as the Baby Boomer generation ages will cause unprecedented increases in the number of individuals with Alzheimer’s. It is estimated that by 2025 the number of Wisconsin residents with Alzheimer’s age 65 and older will increase by 30% to a projected total of 127,000 (Alzheimer's Association, 2012).
Hippocampus is a small, curved region, which exists in both hemispheres of the brain and plays a vital role in emotions, learning and acquisition of new information. It also contributes majorly to long term memory, which is permanent information stored in the brain. Although long term memory is the last information that can be forgotten, its impairment has become very common nowadays. The dysfunction is exemplified by many neurological disorders such as amnesia. There are two types of amnesia, anterograde and retrograde. Anterograde amnesia is inability in forming new information, while retrograde refers to the loss of the past memory. As suggested by Cipolotti and Bird (2006), hippocampus’s lesions are responsible for both types of amnesia. According to multiple trace theory, the author suggests that hippocampal region plays a major role in effective retrieving of episodic memory (Cipolotti and Bird, 2006). For example, patients with hippocampal damage show extensively ungraded retrograde amnesia (Cipolotti and Bird, 2006). They have a difficult time in retrieving information from their non-personal episodic events and autobiographical memory. However, this theory conflicts with standard model of consolidation. The difference between these theories suggests that researchers need to do more work to solve this controversy. Besides retrieving information, hippocampus is also important in obtaining new semantic information, as well as familiarity and recollection (Cipolotti and Bird, 2006). For instance, hippocampal amnesic patient V.C shows in ability to acquire new semantic knowledge such as vocabularies and factual concepts (Cipolotti and Bird, 2006). He is also unable to recognize and recall even...
Pah-Lavan, Z. (2006). Alzheimer's disease: the road to oblivion. Journal of Community Nursing, 20(5), 4. Retrieved from EBSCOhost.
Marieb, E. N., (2006). Essentials of human anatomy and physiology. San Francisco, CA: Benjamin Cummings.
Alzheimer’s disease was first defined in 1906 by a German psychiatrist, Alois Alzheimer. Alzheimer's disease is the most common form of dementia. It is a progressive brain disorder in which the nerve cells in the brain gradually die off. It is estimated that 26 million people world-wide are afflicted by Alzheimer’s and of those, approximately 4.5 million live in the United States. It is said to be the seventh leading cause of death in the USA and the fifth leading cause of death for those over age 65. Seventeen percent of women and ten percent of men age 55 and older can expect to develop Alzheimer’s (apa.org, 2009). Researchers report that this disease is more prevalent in African Americans and Hispanics than in whites (Crandell, Crandell, and Zanden, 2009, p. 578).
Introduction to Human Anatomy and Physiology Third Edition by Eldra Pear Soloman (pgs. 51 and 58)
Memory plays a significant role in the everyday lives of people of all ages. It allows them to recall information and remember skills that were learned in the past. Memory also organizes past information to help people make current and future decisions. However, imagine forgetting the names of close family members or not having the ability to find your keys every time you want to leave the house. These are some of the struggles that people with Alzheimer’s disease face daily. Alzheimer’s disease was first identified by German neurologist Alois Alzheimer in 1906, and was discovered to have an overpowering effect on explicit memory loss (Gruetzner, 1988). There are two types of Alzheimer’s disease – early onset and late onset. Early onset occurs in patients who are diagnosed before the age of 65 whereas late onset occurs in patients who are diagnosed after the age of 65. In the early stages of Alzheimer’s disease, short-term memory is often lost. As Alzheimer’s disease progresses, problems with long-term memory begin to develop, in addition to short-term memory impairments. Although a lot is known about the symptoms of Alzheimer’s disease, the cause has not been conclusively identified. However, as research continues, new theories about the cause of Alzheimer’s disease are being proposed. This has led to a controversy over whether Alzheimer’s disease is caused by genetics or environmental influences (Gruetzner, 1988).
degeneration 3 A nerve cell has numerous axons and dendrites coming out of it. A neurofibrillary tangle is when the neuron changes. A number of dendrites are missing and the nucleus is filled with protein filaments resembling steel wool. Although all elderly people have a few of these helix shaped bundles in their brain as they are normal indicators of aging, Alzheimer's patients have. more than usual.
I will first be discussing declarative memory, which is characterized by knowledge of facts and events. Much of our current knowledge of the structure and substrates of declarative memory derives from studies of amnesiac patients, from which we can derive two primary findings: declarative memory is separate from other forms of memory such as working and non-declarative memory, and function of declarative memory is dependent on structures
...elopments and deciding to now gain more knowledge about genetic, biological and environment factors do this disease and see if there could be further treatments for these specific areas. But doctors and researches will always explain that there is no full treatment but many various treatments to slow this disease down where it affects the brain the most. By doctors and researchers taking their understanding of this disease further, it can bring family and friends closer together and allow people to fully understand this devastating disease that is effecting their loved ones. It will also allow people to understand with cop with this disease and even treatments will not over come Alzheimer’s disease from taking over. But for now treating this disease will be difficult, due to it can never being able to be fully treated by this distorted disease known as Alzheimer’s.
Alzheimer’s disease (AD) is a progressive, terminal, degenerative brain disease. It is the fourth leading cause of death in adults and currently affects over four million people in the United States. This number is expected to increase over the next several years as the baby boomers age, until it reaches fourteen million by the year 2025.
Purpose – I want to bring awareness to the fact that Alzheimer’s disease is an irreversible, progressive brain disorder that slowly destroys memory and thinking skills, and eventually the ability to carry out the simplest tasks.
...hed and streamlined to allow for earlier diagnosis. In the case of tertiary prevention, the pharmaceutical companies have a huge financial incentive to create a cure for Alzheimer’s but that is not enough. More government funded research should be dedicated towards finding methods to delay or cure Alzheimer’s disease. The baby boomer generation has already entered their 60’s. As people live longer, as a result of new treatments for common killers such as heart disease and cancer, the chances that they will succumb to Alzheimer’s increases. Failing to find preventative or curative measures will be costly. On a personal level, Alzheimer’s disease slowly attacks cognitive function-the higher thought processes; individuals degenerate into infantile dependents. The cost of caring for increasing numbers of such dependents will be a burden on both family and society.
WIMO, A., WINBLAD, B., AGUERO-TORRES, H. & VON STRAUSS, E. 2003. The magnitude of dementia occurrence in the world. Alzheimer Dis Assoc Disord, 17, 63-7.
Mykenzie Moyle Ms. Douglass English I, P.4 16 May 2014 Research Paper Alzheimer’s Disease is formed in the brain but, yet, has no known cure or treatment. Alzheimer’s disease has many symptoms. Memory is the biggest symptom along with mood swings and having a hard time keeping up with a conversation. A patient with Alzheimer’s goes through 7 stages; The first stage, which is misplacing things or forgetting what something is used for, second stage, they start losing more of their memory and they begin to forget where they are or what they are doing, the third, fourth and fifth begin to mentally decline and need someone to take care of them and worsen over time.