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Does Brain-Derived Neurotrophic Factor Have an Effect in Depression Levels in Elderly Women

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This study was done to test whether or not brain-derived neurotrophic factor (BDNF) has an effect on depression levels in elderly women, and if it is increased my exercises. They chose to compare aerobic exercises with strength exercise in women over the age of 65. Participants were voluntary. A study testing BDNF has been done most frequently in younger individuals, but not in the elderly. The Ethics and Research Committee of the Universidade Federal de Minas Gerais/UFMG approved this study, and every patient signed a free, informed consent (Pereira et al, 2010).
This study originally started with 472 participants. 21 of these participants either dropped out or were excluded form the trail before it started, due to cancer, rheumatoid arthritis, or other health conditions. Of the remaining 451 participants that were in the trial, group one had 229 participants and group two had 222 participants. Group one ended with 181 participants and group two ended with 167 participants due to health and family problems (Pereira et al, 2010). This is a relatively small sample size if these results wanted to be a projection of an entire population. Since it is one of the first studies of this topic to be done on the elderly, it is a good place to start. If this information was to be used as evidence-based practice, a larger group should be studied first.
This study was a randomized controlled trial. It was a quantitative study, and they based their results by using the GDS method for testing level of depression (Pereira et al, 2010). These participants were recruited from within the community by posting in local newspapers and community centers. Each participant was randomly assigned to one of the exercise groups. The study participants were b...


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...pening in the brain during exercise that is related to depression. That would help us to further understand why exercise decreases depressive symptoms.


References
Critical Appraisal Skills Programme (2010). [Randomized controlled trial]: Making sense of evidence about clinical effectiveness. United Kingdom. Accessed online at http://www.casp-uk.net
Pereira, D. S., de Queiroz, B. Z., Miranda, A. S., Rocha, N. P., Felicio, D. C., Mateo, E. C., et al. Effects of Physical Exercise on Plasma Levels of Brain-Derived Neurotrophic Factor and Depressive Symptoms in Elderly Women—A Randomized Clinical Trial. Archives of Physical Medicine and Rehabilitation, 1443-1450. Retrieved April 27, 2014, from https://wisconsin.hosts.atlas-sys.com/nonshib/GZE/illiad.dll?Action=10&Form=75&Value=2046267
Polit, D. & Beck, C. (2010). Essentials of Nursing Research: Appraising Evidence for



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