Diagnosis is the process of identifying a particular condition via a systematic way. Differential diagnosis is the method of pinpointing all possible aetiological factors that are related with all clinical signs and symptoms and thus, precisely differentiating diagnosis until an accurate conclusion is made. Differential diagnosis is essential especially in field of neurology where many diseases share similar characteristics but has no definite examination or neurological test: Parkinsonism, migraine, amyotrophic sclerosis and also, multiple sclerosis. Differential diagnosis of multiple sclerosis is very broad in nature. About hundred conditions can imitate multiple sclerosis, this figure is rather an under-estimate. However, it is impractical and tedious to perform such differential diagnosis routinely to rule out multiple sclerosis. Instead, key features of each patient allow a rational consideration of relevant alternate diagnosis. Potential multiple sclerosis “mimics” can be easily distinguished from other patients as most relapsing onset patients have either optic neuritis or myelitic syndromes. 1. Monosymptomatic demyelination It is a single attack of optic neuritis, horizontal myelitis or any other lesions limited to one anatomic localization at one point in time. It represents first incident of multiple sclerosis. It shares similar symptoms and covers a broad spectrum of other neurologic disorders. More than half of the cases have abnormal MRI, with other subclinical lesions in other parts of central nervous system. Time factor differentiates this disease from multiple sclerosis. Presence of another lesion after MRI done a month later will imply multiple sclerosis. 2. Schilder disease It is the demyel... ... middle of paper ... ...d may be increased. Meningeal abnormalities are often seen in MRI. Skin, lung and lymph node biopsies are definitive. 15. Anterior ischemic optic neuropathy (AION) It is the arrest of second cranial nerve because of vascular disorder, either vasculitic or artheroclerotic. Subacute or sudden monocular vision loss may resemble optic neuritis as in multiple sclerosis. The disease is commonly affecting elderly patients (more than 50 years) with lipid plaques risk factors. However, no other symptom of multiple sclerosis is seen. Normal cerebrospinal fluid and MRI scanning are evident. 16. Cogan syndrome It is the disease of interstitial keratitis with deafness and vertigo attacks. Ataxic incidents may occasionally report. Abnormal MRI scans are of rare complaints. Deafness is very rare incidence in multiple sclerosis. Plus, cerebrospinal fluid readings are normal.
Parkinson’s disease is not a condition that is necessarily easy to be diagnosed. Therefore, the individual is advised to see a Parkinson’s specialist to receive the most accurate diagnosis and consider what the best course of treatment for the individual would be.
MS causes a degeneration of the myelin around axons due to the killing off of oligodendrocytes, which are cells that make up the myelin sheath of an axon; losing myelin decreases the neuron’s ability to propagate an action potential. Since this disease affects the central nervous system, MS can cause dysfunction of both the sensory and the motor aspects of the body. Some common sensory complaints(Lundy-Ekman, 2007) of MS are tingling, numbness, and/or paresthesia in the affected area, which is variable but typically involves one or more limbs (Palace, 2001), as well as partial blindness in one eye, a decrease in vision acuity, and double vision. Lhermitte’s sign, which is a radiating shock that travels down the back or limbs, is another common characteristic of MS that aff...
WORLD HEALTH ORGANISATION, 1997. Tabular list of neurological and related disorders. In: WORLD HEALTH ORGANISATION, ed. Application of the International Classification of Diseases to Neurology. Canada: World Health Organisation, p. 153.
Multiple sclerosis (MS) is generally thought to be an autoimmune disease that attacks the myelin sheaths, or oligodendrocytes that cover nerve axons in the central nervous system (PubMed Health 2013). This immune response causes inflammation, which triggers immune cells to destroy axons “along any area of the brain, optic nerve, and spinal cord” (PubMed Health 2013). When the myelin sheath “is damaged, nerve signals slow down or stop” thus hindering the propagation of action potentials and limiting function (PubMed Health 2013).
What is Multiple Sclerosis? Ms is an Autoimmune disorder. When the disorder progresses the nerves will be damaged and so the damaged is caused by inflammation. Another thing is the cells that were protected by a layer will be damaged as well. So when you have the damaged cell this will lead to the brain and the spinal cord. So that is what MS is.
Parkinson's Disease is a mysterious disease that affects the central nervous system and can be very difficult to treat and live with. It is classified as a motor system disorder but is a progressive, chronic disease resulting in
PD is separated into stages according to the symptoms and degree of disability Stage 1 is mild disease with unilateral limb involvement. Whereas the patient with stage 5 disease is completely dependent in all ADLs. Other classification refer simply to mild, moderate, and ...
According to National Multiple Sclerosis Society, Multiple Sclerosis (MS) is an unpredictable, often disabling disease of the central nervous system (CNS) that disrupts the flow of information within the brain, and between the brain and body. The central nervous system (CNS) comprises of the brain and the spinal cord. CNS is coated and protected by myelin sheath that is made of fatty tissues (Slomski, 2005). The inflammation and damage of the myelin sheath causing it to form a scar (sclerosis). This results in a number of physical and mental symptoms, including weakness, loss of coordination, and loss of speech and vision. The way the disease affect people is always different; some people experience only a single attack and recover quickly, while others condition degenerate over time (Wexler, 2013). Hence, the diagnosis of MS is mostly done by eliminating the symptoms of other diseases. Multiple sclerosis (MS) affects both men and women, but generally, it is more common in women more than men. The disease is most usually diagnosed between ages 20 and 40, however, it can occur at any age. Someone with a family history of the disease is more likely to suffer from it. Although MS is not
Wiley Online Library, 2013. The Epidemiology of Multiple Sclerosis [online] Available at: <. http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0404.1997.tb08143.x/abstract> [Accessed 05 December 2013].
The clinical picture of the disease is rich and variated. Usually it starts with motor symptoms together with visual disturbances. The later progression is depending on the part of the CNS affected. MS can present itself in several clinical courses with the relapsing remmitting beeing the most common in the begging. The secondary progressive course is a sequent and gives a much worse prognosis. The benign form, even though it’s not well defined, is usually a random find in MRI and no clinical symptoms. In the most severe cases MS can lead to death.
Parkinson disease is their affliction. Although Parkinsonism has been around almost as long as recorded history, there is yet to be found a cause or a cure. Medications tame the symptoms and prolong life, but are incapable of reversing the disease progression.. Diagnosis relies exclusively upon clinical signs and symptoms, because almost all laboratory and radiography tests are normal in the Parkinson patient. For this reason early diagnosis is very difficult.
Multiple sclerosis is a chronic disease of the central nervous system. It is understood as an autoimmune disease, a condition where the body’s immune system mistakenly attacks normal tissues. In Multiple Sclerosis, the patient’s own cells & antibodies attack the fatty myelin sheath that protects and insulates nerve fibres in the brain and spinal cord, the two components of the CNS. This ultimately causes damage to the nerve cells and without the insulation the myelin sheath provides, nerve communication is disrupted. Hence, Multiple Sclerosis is characterized by symptoms that reflect central nervous system involvement (Luzzio, 2014).
It is also estimated that approximately two and half million people are living with the disease... The name multiple sclerosis refers to the scars that are present in the brain and spinal cord is seen on an MRI. An autoimmune disorder is where a person’s immune system mistakes its own white blood cells as invaders and begins to attack itself damaging healthy body tissue. In these types of disorders, the immune system cannot tell the difference between healthy cells and antigens, which are foreign invaders like bacteria and viruses. Because of the damage, it does to the nerve cells; nerve signals can either slow down or stop completely. Inflammation, or the body’s reaction to infection, is what causes this nerve damage to happen. Multiple sclerosis is most commonly seen in the brain, optic nerve, and spinal cord and often leads to physical and cognitive
"Secondary Parkinsonism: MedlinePlus Medical Encyclopedia." U.S National Library of Medicine. U.S. National Library of Medicine, n.d. Web. 11 May 2014.
A proper classification method removes the guess work for diagnosis. It serves as a guide to reach a precise diagnosis. Diagnostic criterion helps the clinician to make an interim diagnosis and clarify it in further assessments.