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Pathophysiology of acute renal failure papers
Short question for acute renal failure
Pathophysiology of acute renal failure papers
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Problem: A man arrives at a clinic with complaints of asthenia, malaise, headache, weight gain, and a decrease in urination. A tentative diagnosis of acute renal failure is made.
1. Explain the pathophysiology of acute renal failure. Include prerenal, intrarenal, and postrenal causes.
The kidneys are responsible for multiple jobs that are necessary for the survival of the human body. Some of its functions are filtering wastes from the blood, regulate blood pressure, and regulate salt and water balances in the body. The upper and lower tract of the urinary system is commonly affected by problems such as infection and incontinence. However, in some cases an individual may develop acute renal failure. Its rapid development impairs the kidneys unless the underlying cause of the problem is found immediately and treated properly.
When the cardiovascular system fails to perfuse the kidneys adequately with blood, the result is acute renal failure. In acute renal failure (ARF) the kidneys suddenly loses its ability to excrete wastes, concentrate urine, conserve electrolytes, and maintain fluid balance (Schrier, Wang, Poole & Mitra, 2004). The glomerulus, or the capillary network inside the Bowman’s capsule, is responsible for the entire filtrating system of our kidneys. Blood enters the kidneys through the renal arteries and leaves through the renal veins. The strength of pressure exerted onto the kidneys is what makes the glomerular filtration work. Nevertheless, this pressure depends upon the flow of blood and the resistance between the afferent and efferent arterioles. At any given time when the flow of blood is obstructed, the glomerular filtration rate (GFR) decreases. This pathologic pathway leads to the underlying cause of acute renal failure. It consists of three mechanisms: prerenal, intrarenal, and post renal or obstructive (Workeneh, 2013).
When there is no renal perfusion, the glomerular filtration rate (GFR) is undermined. Fluid leaving the glomerulus and Bowman’s capsule is filtered and enters the convoluted tubules. During prerenal, these tubules and the glomerulus still remain normal. Some of the prerenal causes include hypovolemia, dehydration, medications such as diuretics, and obstruction of the renal artery or vein (MedicineNet, 2013). The result of the prerenal phase is the most common cause of acute renal failure because it eventually leads to hypoperfusion and ischemia. In intrarenal, the kidney is damaged and the glomerulus and tubules are the ones chiefly affected. When there is tubular damage, the afferent arterioles constrict causing the vessels to get narrow and eventually make it difficult for blood to flow.
A 54 year old female was presented with complaints of lethargy, excessive thirst and diminished appetite. Given the fact that these symptoms are very broad and could be the underlying cause of various diseases, the physician decided to order a urinalysis by cystoscope; a comprehensive diagnostic chemistry panel; and a CBC with differential, to acquire a better understanding on his patient health status. The following abnormal results caught the physician’s attention:
The kidneys play a major role in the blood composition and volume , the excretion of metabolic wastes in the urine, the control the acid/base balance in the body and the hormone production for maintaining hemostasis. The damages to the GBM in the glomeruli alter filtration process that allows the protein and red blood cells to leak into the urine. Loss of protein like albumin in the urine results in a decrease of their level into the blood stream. Consequently, this patient’s blood reveals a decreased albumin (Alb) value of 2.9 g/dL, decreased serum total protein value of 5 .0 g/dL and in the urine presents of the protein and the RBCs. Impaired filtering capacity result in inability of kidneys to excrete excretory products like electrolytes and metabolic waste products that will then accumulate in the blood. Furthermore, inability of distal convoluted tubules to excrete sufficient quantities of potassium, sodium, magnesium (Mg), chloride (Cl), urea, creatinine (Cr), alkaline phosphatase (Alk Phos), and phosphate (PO4) results in their elevation in the blood. His laboratory values reveal an increased of sodium value of 149 meq/L, an increase of potassium value of 5.4meq/L, increased chloride value of 116 meq/L, increased blood urea nitrogen (BUN) serum of 143 mg/dL, and increased creatinine serum of 7.14 mg/dL. The other abnormal blood tests associated with a loss of kidneys’ filtration property identify in this patient are related to an increase of alkaline phosphatase value of 178 IU/L, increased magnesium value of 3.8mgdL, and increased phosphate (PO4) value of 5.9 mg/dL .
Renin angiotensin system activation: Because of decreased blood flow to the kidneys the compensatory mechanisms activate to hold on to sodium and water. When the Blood flow is decreased Angiotensin II is released causing vasoconstriction
Acute renal failure causes can be classified as pre-renal, intra-renal or post renal. Intrarenal Acute renal failure are those that directly attack the kidney such as an infection, glumerulonephritis, and diabetes. A common intrarenal condition is the acute tubular necrosis, where epithelial layers of the nephrons become damaged leading to changes in urine concentration, waste filtration, electrolytes and acid base balance. There are three phases of acute tubular necrosis they are initiation, maintenance usually last one to two weeks, and recovery phase where patients will be put on diuretics and will have a slow return of renal function. Patients that are at risk of developing ATN are patients that have azot...
1 in 3 Americans Adults are currently at risk for developing kidney disease. What is acute renal failure, when your kidneys functions all of a sudden stop working and your kidneys are the body’s filter which remove waste products and help balance water, salts and minerals especially electrolytes in your blood when your kidneys stop working you end up building all the products in your body that need to be filtered and eliminated. The pathophysiology of Acute Renal Failure are due to three main causes Pre-renal, Intra-renal, and Post renal. Pre-renal is a sudden drop in blood pressure or interruption of blood flow to the kidneys from illness or sever injury. Intra-renal is direct damage to the kidneys by inflammation of drugs, infection, toxins or reduced blood supply. Post-renal is a sudden obstruction of urine flow because of enlarged prostate bladder tumor, kidney stones, or injury.
Pathophysiology There are three different stages of acute renal failure; prerenal, intrarenal, and post renal. Prerenal failure is a result from an illness or injury that causes obstruction of blood flow to the kidneys, called hypoperfusion. Hypotension, hypervolemia and inadequate cardiac output are all examples that could cause prerenal failure. According to Lippincott Williams and Wilkins (2009), “prerenal azotemia, excess nitrogenous waste products in the blood, account for 40% to 80% of all cases of acute renal failure” (p. 307). Intrarenal is when there is direct damage to the kidney tissue by either inflammations, drugs, infections or a reduction in the blood supply to the kidney. Post renal is when there is an obstruction of the urine flow. Causes of obstruction could be enlarged prostate gland, kidney stones, bladder tumor or injury. There are four phases of acute renal failure; onset, oliguria, diuresis and recovery. The onset phase can last hours or up to days. The BUN and creatinine levels may start to increas...
J.P., a 58 year old female, presents to the Emergency Room on March 18th. She has a past medical history of cervical cancer, atheroembolism of the left lower extremity, fistula of the vagina, peripheral vascular disease, neuropathy, glaucoma, GERD, depression, hypertension, chronic kidney disease, and sickle cell anemia. She complains of right lower extremity pain accompanied by fatigue, a decreased appetite, increased work of breathing, burning urination, and decreased urine output for three days. Upon admission, a complete physical assessment was performed along with a blood and metabolic panel. The assessment revealed many positive and negative findings.
The renal disease are common nowadays .The acute renal failure is a medical term means that the kidneys stopped from working and not able to clear toxins from body ,not able to maintained a stable electrolyte balance inside the body and not able to secret the extra fluid as urine outside the body. The renal replacement therapy (RRT) or dialysis has been discovered on 1913 by Able, Rowntree and Turner in London, UK.
United States Renal Data System (USRDS). (2008). Annual data report: Incidence and prevalence. Retrieved July 8, 2009, from http://www.usrds.org/2008/pdf/V2-02-2008.pdf
Healthy kidneys clean the blood by filtering out extra water and wastes. They also make hormones that keep your bones strong and blood healthy. When both of your kidneys fail, your body holds fluid. Your blood pressure rises. Harmful wastes build up in your body. Your body doesn't make enough red blood cells. When this happens, you need treatment to replace the work of your failed kidneys.
Prerenal failure its common to have a decrease in urine output but not always. Fluid retention which commonly causes swelling in distal extremedies,slumberous, dyspnea, chronic fatigue and nausea. The man who arrived into the clinic had complained about almost all symptoms of acute renal failure. Intrinsic renal failure is when the direct damge causes the kidney to lose its function. Most common intrinsic renal failure is acute tubular necrosis where the small filtering
blocked has now shut down. This kidney, if left untreated for just a few days,
Kidney damage can occur from hypertension which causes blood vessels in the kidneys to shrink and harden; infections travelling though the bloodstream; long-term and uncontrolled diabetes, and genetically inherited kidney problems. (Edith Cowan University, 2001-2004)
Kidney Function Introduction and definition of terms: The kidneys are the main organs in the urinary system. They filter waste products out of blood from the renal artery. These are then excreted. Useful solutes are reabsorbed into the blood. They also have a major homeostatic role in the body, and help to control the water content (osmoregulation) and pH of the blood.
Furthermore, they are involved in the reabsorption of nutrients in the bloodstream and they can regulate the acidity of the blood. Besides the regulation of the fluids and ions, the kidneys are also responsible for the regulation of many different hormones that are involved in homeostasis and metabolism. Because of their importance in the regulation of substances in the body, when the kidneys stop working properly all the body is influenced by that creating disequilibrium in the maintenance of homeostasis and control of all the metabolic functions which can indirectly cause other problems to the body.... ... middle of paper ... ...