Courtship Behavior of Drosophila melanogaster

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Introduction

“All animals exhibit innate behaviors that are specified during their development.” Drosophila melanogaster (fruit fly) males exhibit complex sexual courting behaviors towards females; these sexual behaviors are only directed from males towards females and are not present in females. The fruitless (fru) gene, which is spliced differently in males and females, has been shown to perhaps have something to do with this male-fruit-fly-attributed innate courtship ritual. This research paper seeks to determine whether this fru gene is a “switch” gene that is “necessary and sufficient to specify male courtship behavior and sexual orientation.” Gene targeting was used to splice the fru gene and exchange it between male and female fruit flies to determine differences in courtship behavior that could be attributed to the loss or gain of the fru gene. From this experiment, insight into the importance of this gene in male courtship behavior can be attained.

Results

Fru regulates sexual behavior but not gross sexual anatomy

One of the conclusions which were reached by the researchers was that fru regulates sexual behavior, not the gross anatomy of the drosophila. In drosophila, the sex determination hierarchy separates into two parts. Like in fru, the doublesex gene (dsx) is spliced differently and it produces dsxM or dsxF. These dsx proteins do not have to do with the sexual behavior of drosophila, but rather they have to do more with their morphological development. This became evident because when there is a male drosophila which does not have dsxM he still courts but possesses female anatomy, and vice versa. This brought the researchers to the conclusion that the dsx indeed does not have to do with...

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...established recently through exact gene manipulations. FruM has four unique aspects that stand out in order to determine other switch genes. First, it acts during the development of the individual and creates a potential for a behavior and does not influence the behavior directly. Second, to our current knowledge it is involved in most aspects of the behavior. Third, “loss-of-function mutations do not result in a general impairment of neural function, but a specific behavioral deficit.” Fourth, it is required to affect the role in the gene.

References

Demir, E., and Dickson, B. J. (2005). Fruitless Splicing Specifies Male Courtship Behavior in Drosophila. Cell 121; 785-794.

"Glossary." Geron. 2004. 1 Dec. 2006 showpage.asp?code=prodgl>. Purves et al. Life: The Science of Biology. Seventh Ed. Sinauer Associates, Inc., 2004.

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