Animal and Cell Models for Human Nutrition

Assignment

Animal and Cell Models for Human Nutrition

Table of contents

1. Discussion of study and the process being investigated………………………….3

1.1. Application to human studies……………………………………………3

2. What is known about the mechanisms involved? ………………………………..3

3. The approach and findings of the paper

3.1. Methods……………………………………………………………………4

3.2. Results.……………………………………………………………........….5

3.3. Findings……………………………………………………………………5

4. The different experimental models used to study this particular process

4.1 Animal models……………………………………………………………..6

4.1.1 Rodent models…………………………………………………….6

4.1.1.1 Mouse models…………………………………………….6

4.1.1.2 Rat models………………………………………………..7

4.1.2 Non-human primates models.……………………………………..8

4.2 Advantages and Disadvantages of the experimental model used in the chosen paper……………………………………………………………………9

5. References………………………………………………………………………...10

Selected paper: Elahi M.M., Cagampang F.R., Mukhtar D., Anthony F.W., Ohri S.K., Hanson M.A. (2009). Long-term maternal high-fat feeding from weaning through pregnancy and lactation predisposes offspring to hypertension, raised plasma lipids and fatty liver in mice. British Journal of Nutrition, 102:514–519

http://journals.cambridge.org/action/displayFulltext?type=1&fid=6015296&jid=BJN&volumeId=102&issueId=04&aid=6015288&bodyId=&membershipNumber=&societyETOCSession=

1. Discussion of study and the process being investigated

The western diet has seen an increase in the consumption of refined foods with a high glycaemic index and fat content over the past few decades. Diets high in these refined foods may affect early development and susceptibility to diseases such as the metabolic syndrome in later life (Elahi et al, 2009). Elahi et a...

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...y-London, 589(16), 3969-3981. doi: 10.1113/jphysiol.2011.212324

Parente, L. B., Aguila, M. B., & Mandarim-de-Lacerda, C. A. (2008). Deleterious effects of high-fat diet on perinatal and postweaning periods in adult rat offspring. Clinical Nutrition, 27(4), 623-634. doi: 10.1016/j.clnu.2008.05.005

Tardif, S. D., Coleman, K., Hobbs, T. R., & Lutz, C. (2013). IACUC Review of Nonhuman Primate Research. Ilar Journal, 54(2), 234-245. doi: 10.1093/ilar/ilt040

Warden, C. H., & Fisler, J. S. (2008). Comparisons of diets used in animal models of high-fat feeding. Cell Metabolism, 7(4), 277-277. doi: 10.1016/j.cmet.2008.03.014

Williams, L., Seki, Y., Vuguin, P. M., & Charron, M. J. (2014). Animal models of in utero exposure to a high fat diet: A review. Biochimica Et Biophysica Acta-Molecular Basis of Disease, 1842(3), 507-519. doi: 10.1016/j.bbadis.2013.07.006