An Overview of Oral Candidiasis

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Candida albicans is a harmless commensal yeast which becomes pathogenic when environmental changes trigger the virulence factors of the organism. Hence Candida species are opportunistic pathogens in susceptible individuals. Oral infection caused by C. albicans known as oral candidiasis or candidosis. However, C. albicans exist in the mouths of 80% of healthy individuals. Any alteration in the environment of oral cavity can change the presence of candida from commensal to pathogenic. This translation in the status of candida is due to many predisposing factors. In the past, oral candidiasis was thought to affect mainly elderly and very young population. Recently, the incidence of oral candidiasis increased greatly with the intensification of HIV infection and immunosuppressive chemotherapy (1, 2). Oral candidiasis colonize 5% to 7% of newborn less than one month old. The infection also estimated to affect 9% to 31% of AIDS patients and nearly 20% of cancer patients (3). This review discuss the possible causes, the types of oral candidiasis, treatment and management strategies.

Laboratory Identification

Candida can be obtained by rubbing a sterile cotton swab over the affected tissue lesions in the mouth and then inoculated in Sabouraud's dextrose agar (SDA). Another technique is using sterile foam pad that has been dipped in a liquid medium, such as Sabouraud's broth. The pad is then placed on the affected lesions in the mucosal cavity for 30 seconds and then transferred to an agar for culture. The last method is the oral rinse technique which require the patient to hold a sterile phosphate buffered saline in the mouth for one minute. The solution is then inoculated on an agar media at 37oC for 24-48 hours (1).

Candida species...

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