Table of Contents
Introduction………………………………………………………………………..
Background…………………………………………………………………………
Previous Work……………………………………………………………………
Results and Discussion……………………………………………………………
Future Work………………………………………………………………………..…
Experimental Procedures………………………………………………………………
References………………………………………………………………………………
Introduction
Synthesis of molecules is very important in the development of natural products used in medicine today.1 However, there are many problems with the current synthesis method that conflict with many of the guidelines in the 12 Principles of Green Chemistry and are potentially hazardous.2 The proposed research plan includes the formation of a salt by allylation followed by the Aza-Claisen rearrangement which has shown success using benzothiazole. Ultimately, this research seeks to eliminate these costly, inefficient factors and create a more productive, safer plan to achieve the natural products used in medicine today.
Azoles are 5-membered ring heterocycles containing a nitrogen atom and at least one other non-carbon atom.
Azole derivatives are most frequently found in medicines that treat fungal infections. Some very common examples are fluconazole, miconazole, and ketoconazole which work by inhibiting cytochrome P450-dependent enzymes that are part of ergosterol synthesis within the cell membrane.3
Azoles can also be found in medication that treats AIDS, cancer, and acid reflux disease. The synthesis of azole derivatives is a key step in acquiring the compounds used in these drugs; and because azoles are widely used in today’s society, it is important to make this process as efficient as possible.
Over the past few decades, people in our society have become much more aware o...
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...ecent Advances in Carbon–Carbon Bond-Forming Reactions Involving Homoenolates Generated by NHC Catalysis. Nair, V.; Vellalath, S.; Babu, B. P. Chem. Soc. Rev. 2008, 37, 2691-2698.
11. Addition of N-Heterocyclic Carbenes to Imines: Phenoxide Assisted Deprotonation of an Imidazolium Moiety and Generation of Breslow Intermediates Derived from Imines. Simonovic, S.; Frison, J.-C.; Koyuncu, H.; Whitwood, A. C.; Douthwaite, R. E. Org. Lett. 2009, 11, 245-247.
12. Anti-Plasmodium Activity of Imidazolium and Triazolium Salts, Bioorganic and Medicinal Chemistry. Jason Z. Vlahakis, Carmen Lazar, Ian E. Crandall , Walter A. Szareka. 2010, 18, 6184-6196.
13. 13C NMR Spectroscopic Determination of Ligand Donor Strengths Using
N-Heterocyclic Carbene Complexes of Palladium(II). Han Vinh Huynh,* Yuan Han, Ramasamy Jothibasu, and Jie An Yang. 2009, 5395-5405.
This week’s lab was the third and final step in a multi-step synthesis reaction. The starting material of this week was benzil and 1,3- diphenylacetone was added along with a strong base, KOH, to form the product tetraphenylcyclopentadienone. The product was confirmed to be tetraphenylcyclopentadienone based of the color of the product, the IR spectrum, and the mechanism of the reaction. The product of the reaction was a dark purple/black color, which corresponds to literature colors of tetraphenylcyclopentadienone. The tetraphenylcyclopentadienone product was a deep purple/black because of its absorption of all light wavelengths. The conjugated aromatic rings in the product create a delocalized pi electron system and the electrons are excited
The goal of this lab is to exemplify a standard method for making alkyne groups in two main steps: adding bromine to alkene groups, and followed by heating the product with a strong base to eliminate H and Br from C. Then, in order to purify the product obtained, recrystallization method is used with ethanol and water. Lastly, the melting point and IR spectrum are used to determine the purity of diphenylacetylene.
middle of paper ... ... The world we live in today is becoming more and more apathetic. Most people only care about their personal well-being and perhaps those who are closest to them. Some people have little or no knowledge of the world around them and what’s happening in it, they have little concern if the subject does not directly involve them.
When we look back at the modern world we live in, it is clear that
In this experiment, four elimination reactions were compared and contrasted under acidic (H2SO4) and basic (KOC(CO3)3) conditions. The acid-catalyzed dehydration was done on 2-butanol and 1-butanol; a 2ᵒ and 1ᵒ alcohol, respectively. The base-induced dehydrobromination was performed on 2-bromobutane and 1-bromobutane; isomeric halides. The stereochemistry and regiochemistry of the four reactions were analyzed by gas chromatography (GC) to determine product distribution (assuming that the amount of each product in the gas mixture is proportional to the area under its complementary GC peak. The three butene products have been verified that they elute in the following order: 1-butene, trans-2-butene, and cis-2-butene.
society today is hyper-aware of the ?example? that it sets for the future generation; in
since been expanded by the media to the point that myself and my peers are
The purpose of conducting this experiment was to synthesise and characterise for the preparation of benzocaine via a fishcer esterification reaction by the means of amino benzoic acid alongside ethanol. The product was also precipitated from a solution in order to gain a pH of 8.The secondary aim was to esterify the reaction in an equilibrium reaction catalysed via the addition of acid shown below:
keep up as they are going, a whole new generation of close minded people, and feelings of
Thickett, Geoffrey. Chemistry 2: HSC course. N/A ed. Vol. 1. Milton: John Wiley & Sons Australia, 2006. 94-108. 1 vols. Print.
Product 3 was isolated in a low yield of 27% and with some solvent impurities as shown by the analytical techniques but it was indeed synthesised successfully.
Those are just some of the ways Society has changed. So you tell me has society changed for the worst are the better. The proof is in the paper if you ask me. Just go look on social media are just turn your tv on. Society has changed in it’s getting worse as each generation learn how to use a computer are a phone(Boundless35).
Plontke, R. (2003, March 13). Chemnitz UT. TU Chemnitz: - Technische Universität Chemnitz. Retrieved April 1, 2014, from http://www.tu-chemnitz.de/en/
One of the most important uses of organic compounds is in medicine. All living things have four organic molecules - carbohydrates, proteins, lipids and nucleic acids. Without carbon chains and nucleic acids, DNA would not exist. Enzymes which produce chemica...
Technology has advanced to the point where it touches our lives in nearly every conceivable way-we no longer have to lift a finger to perform the most trivial tasks. The wealth of information and science we have learned in the last few centuries have made our lives easier but not always better, especially when concerning civilization as a whole. Ibsen, Freud, and Vonnegut argue that human values have not kept pace with knowledge's unceasing expansion, which has become an anathema for the individual person and deleterious to society's delectation, albeit without people's entire comprehension.